signals: a question of timing
نویسنده
چکیده
Receptor-stimulated Ca 2 signals come in several flavors. The Ca 2 signals can be decoded linearly or by integration of the response. How the duration of the signal conveyed by cytosolic Ca 2 concentration ([Ca 2 ] i ) changes is regulated is not well understood. Liu et al. (Liu, Q., S.A. Walker, D. Gao, J.A. Taylor, Y.-F. Dai, R.S. Arkell, M.D. Bootman, H.L. Roderick, P.J. Cullen, and P.J. Lockyer. 2005. J. Cell Biol. 170:183–190) now report an example of decoding based on the differential regulation of Ras function by two Ca 2 -sensitive Ras inhibitors: Ca 2 promoted Ras activator (CAPRI), which extends the duration of the effect of Ca 2 on Ras activity, and Ras GTPase activating-like protein (RASAL), which functions as a linear decoder of the Ca 2 signal.
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